Certificate in Cancer Immunotherapy


The eight modules of the Certificate in Cancer Immunotherapy program are listed below. Click on each to learn more.

Certificate in Cancer Immunotherapy Modules
Collapse Certificate in Cancer Immunotherapy Module 1: Basic Immunology Concepts

Published August 3, 2020

Course Description
This interactive online course is part of the Certificate in Cancer Immunotherapy program, produced by the Society for Immunotherapy of Cancer (SITC). The purpose of the certificate program is to provide hospitals, medical centers, third-party payers, referring physicians, trainees and patients with an identifiable designation for healthcare providers who can safely and effectively participate in administration of immunotherapies and manage patients treated with these approaches. View all eight modules of the program and a detailed description of the program here.

This course, Module 1: Basic Immunology Concepts, will cover some of the key immunology needed to understand the rest of the certificate program.

Click on image for FREE PREVIEW



Target Audience
The program is available to licensed physicians (U.S. licensed MD / DO or global equivalent). The courses and earning of the certificate (SITC-G; G = graduate) are also available to practicing, licensed NPs, PAs, and PharmDs or global equivalent. RPh degree holders are eligible if they are involved in direct clinical services. The courses are available to others who are not practicing clinicians, but they will not be eligible to earn the certificate.

Faculty
Robert L. Ferris, MD, PhD
Hillman Professor of Oncology
Director, UPMC Hillman Cancer Center
Associate Vice Chancellor for Cancer Research
University of Pittsburgh Medical Center, Pittsburgh, PA

Learning Objectives

Topic At the conclusion of this activity, the participant should be able to:

Basic Properties of the Immune System

  • Describe the differences between innate immunity and adaptive immunity.
  • Describe the differences between humoral immunity and cellular immunity.
  • Describe the concept of self/non-self discrimination and immunologic memory.

Cells and Tissues of the Immune System

  • Distinguish between the basic cell types involved in the immune response and their function, including B cells, T cells, natural killer (NK) cells, monocytes/macrophages and dendritic cells (DC).
  • Describe the architecture and functions of various immunologic tissues including the thymus, spleen, lymph nodes and bone marrow.

Innate Immunity

  • Describe the key components of innate immunity including pattern recognition receptors and cells of the innate immune system.
  • Describe the function and regulation of innate immunity.
  • Describe how activation of innate immunity influences adaptive immune response.
  • Recognize how host cell death influences innate immunity. 

Adaptive Immunity

  • Describe the components of the adaptive immune system including both humoral and cellular immunity.
  • Describe the function and regulation of adaptive immunity.
  • Define immune tolerance.
  • Describe how immune tolerance impacts adaptive immunity.

Antigen Presentation

  • Distinguish class I and class II MHC antigen presentation.
  • Describe antigen uptake, processing and presentation.
  • Describe the concept of cross-presentation.

Effector Immune Responses

  • Identify the cell populations involved in effector immune responses.
  • Describe the different mechanisms of effector functions.
  • Describe how effector functions are regulated.

Inhibitory and Activating Immune Regulation

  • Describe the functions of major suppressive cell populations (regulatory T cells [Treg], and myeloid derived suppressor cells [MDSC])
  • Describe immunological synapses.
  • Describe the molecular mechanisms of immune cell activation.
  • Describe the molecular mechanisms of immune cell inhibition.
  • Distinguish between immune cell activation and inhibition of suppression as a pharmacological strategy.

Integration of the Immune Response

  • Describe how the arms of the immune system interact.
  • List the host factors that influence the immune response.
  • List the environmental factors that influence the immune response.


 


SITC Online Education Disclaimer

 

A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or employing any therapies described in this educational activity.

 



Continuing Education Information

Date of CE Release:  August 3, 2020
Date of CE Expiration: August 3, 2022
Approximate Time to Complete:  90 minutes

Acknowledgement of Financial Commercial Support
No financial commercial support was received for this educational activity.

Acknowledgement of In-Kind Commercial Support
No in-kind commercial support was received for this educational activity.

Satisfactory Completion

Learners must listen to each self-directed audio recording while following along with the visual slides/read the articles, pass the post-test with a score of 80% or higher (unlimited attempts to correctly answer 24 out of 30 questions) and complete an evaluation form to receive a certificate of completion. You must participate in the entire activity as partial credit is not available. If you are seeking continuing education credit for a specialty not listed below, it is your responsibility to contact your licensing/certification board to determine course eligibility for your licensing/certification requirement.

Physicians / Nurses / Pharmacist

In support of improving patient care, this activity has been planned and implemented by Amedco LLC and SITC.  Amedco LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation  Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


Credit Designation Statement – Amedco LLC designates this enduring material for a maximum of 1.50 AMA PRA Category 1 CreditsTM for physicians, 1.50 contact hours for nurses, and 1.50 knowledge-based contact hours for pharmacists. Learners should claim only the credit commensurate with the extent of their participation in the activity.

NOTE to Pharmacists: The only official Statement of Credit is the one you pull from CPE Monitor. You must request your certificate within 30 days of the activity to meet the deadline for submission to CPE Monitor.

ABIM MOC Credit
Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.50 Part 2 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program.

Disclosure of Conflict of Interest
The following table of disclosure information is provided to learners and contains the relevant financial relationships that each individual in a position to control the content disclosed to Amedco.  All of these relationships were treated as a conflict of interest, and have been resolved.  (C7 SCS 6.1-­6.2, 6.5)

All individuals in a position to control the content of CE are listed online. If their name is not listed below, they disclosed that they had no relevant financial relationships.
 

FIRST NAME

LAST NAME

RELATIONSHIP:COMMERCIAL INTEREST

Robert

Ferris

Aduro Biotech, Inc; Amgen; Astra-Zeneca/MedImmune; Bain Capital Life Sciences; BMS; EMD Serono; GSK; Iovance Biotherapeutics, Inc; Lilly; MacroGenics, Inc; Merck; Nanobiotix; Numab Therapeutics AG; Oncorus, Inc; Ono Pharmaceutical Co. Ltd; Pfizer; PPD (Benitec, Immunicum); Regeneron Pharmaceuticals, Inc; Tesaro; Torque Therapeutics; TTMS; VentiRx Pharmaceuticals:Consulting Fees

Astra-Zeneca/MedImmune; BMS; Merck; Tesaro; TTMS:Contracted Research

 

Janssen, Eli Lilly, Scibase, DermTech, BMS, Pfizer:Partner Consulting Fees

 

Regeneron, Janssen, BMS, Abbvie, Novartis, BI, Castle Biosciences, Eli Lilly: Partner Contracted Research


Method of Participation and Request for Credit
During the period 8/3/20 through 8/3/22 participants must read the learning objectives and faculty disclosures and study the educational activity.

If you wish to receive acknowledgment for completing this activity, please follow the steps below:

  1. After completing the course, click My Credit from the left-hand side of the SITC connectED homepage.
  2. Under Pending Credit, click Request Credit for Certificate in Cancer Immunotherapy Module 1: Basic Immunology Concepts.
  3. Ensure that the appropriate Credit Reporting Organization is selected. Click Continue.
  4. Successfully complete both the post-test with passing score of 80% or better (unlimited attempts to correctly answer 24 out of 30 questions) and activity evaluation.
  5. Click Process Credit.
  6. Your Certificate will be available to view in the Submitted Credit section.

For Pharmacists: Upon successfully completing the post-test with a score of 80% or better and the activity evaluation form, transcript information will be sent to the NABP CPE Monitor Service within 4 weeks.


Media
Internet

Hardware and Software Requirements
SITC connectED requires a modern web browser (Edge, Apple Safari, Google Chrome, Internet Explorer 7+) and the ability to listen to audio with the content.

Disclosure of Unlabeled Use
This educational activity may contain a discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Original Course Date: August 03, 2020
On-Demand Release Date: Available Now

Approved Credit:
  • ACCME (MD/DO): 1.50 hours AMA PRA Category 1 Credit(s)
  • ACCME (non-MD/DO): 1.50 hours AMA PRA Category 1 Credit(s)
  • CoP: 0.00 hours Certificate of Participation
  • : 1.50 hours AMA PRA Category 1 Credit(s)™ / ABIM Maintenance of Certification Part 2 Credit
  • ACPE: 1.50 hours Contact Hour
  • ANCC: 1.50 hours Contact Hour

  • MORE INFOMORE INFO Certificate in Cancer Immunotherapy Module 1: Basic Immunology Concepts
    Collapse Certificate in Cancer Immunotherapy Module 2: Basic Cancer Immunotherapy Concepts

    Published October 26, 2020

    Course Description
    This interactive online course is part of the Certificate in Cancer Immunotherapy program, produced by the Society for Immunotherapy of Cancer (SITC). The purpose of the certificate program is to provide hospitals, medical centers, third-party payers, referring physicians, trainees and patients with an identifiable designation for healthcare providers who can safely and effectively participate in administration of immunotherapies and manage patients treated with these approaches. View all eight modules of the program and a detailed description of the program here.

    This course, Module 2: Basic Cancer Immunotherapy Concepts, will cover the biological foundation of cancer immunotherapy, applying the basic immunology you learned in the last module to help lay the foundation for future topics in this program.


    Click on image for FREE PREVIEW


     

     

     

     

     

     

     




    Target Audience
    The program is available to licensed physicians (U.S. licensed MD / DO or global equivalent). The courses and earning of the certificate (SITC-G; G = graduate) are also available to practicing, licensed NPs, PAs, and PharmDs or global equivalent. RPh degree holders are eligible if they are involved in direct clinical services. The courses are available to others who are not practicing clinicians, but they will not be eligible to earn the certificate.

    Faculty
    Hussein Tawbi, MD, PhD
    Deputy Chair and Professor, Department of Melanoma Medical Oncology
    Director of Melanoma Clinical Research & Early Drug Development
    Co-Director, MD Anderson Brain Metastasis Clinic
    University of Texas MD Anderson Cancer Center, Houston, TX
     

    Learning Objectives

    Topic At the conclusion of this activity, the participant should be able to:

    Basis of Tumor Immunosurveillance and Immunotherapy

    • Describe how the immune system recognizes and eliminates cancer cells, including the concept of immunologic memory.
    • Characterize the function of specific immune cell populations in mediating tumor immunotherapy and/or immune suppression.
    • Distinguish between immunosurveillance, immunoediting and immunotherapy of cancer.
    • Identify the implications of immune depleted, excluded and infiltrated tumor microenvironments.
    • Identify how both central and peripheral tolerance can impact immunosurveillance and immunotherapy.
    • Describe the difference between primary and acquired resistance to immunotherapy.
    • Apply concepts of the cancer-immunity cycle to identify how biomarkers inform and influence tumor immunotherapy.

    Immunologic effects of other therapies

    • Describe the immunologic effects of standard cancer therapeutics on the tumor microenvironment and immune system.
    • Describe the potential impact of other, non-cancer agents, on tumor immunotherapy responses and toxicities.
    • Characterize the impact of standard cancer treatments on the efficacy of cancer immunotherapy.
    • Characterize the impact of standard cancer treatments on the toxicity of cancer immunotherapy.
    • Distinguish total body versus focal radiotherapy effects.
    • Recognize the impact of intratumoral injection and other local therapies on the tumor microenvironment and anti-tumor immune response.


     


    SITC Online Education Disclaimer

     

    A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or employing any therapies described in this educational activity.

     



    Continuing Education Information

    Date of CE Release:  10/26/20
    Date of CE Expiration: 10/26/22
    Approximate Time to Complete:  90 minutes

    Acknowledgement of Financial Commercial Support
    No financial commercial support was received for this educational activity.

    Acknowledgement of In-Kind Commercial Support
    No in-kind commercial support was received for this educational activity.

    Satisfactory Completion

    Learners must listen to each self-directed audio recording while following along with the visual slides/read the articles, pass the post-test with a score of 80% or higher (unlimited attempts) and complete an evaluation form to receive a certificate of completion. You must participate in the entire activity as partial credit is not available. If you are seeking continuing education credit for a specialty not listed below, it is your responsibility to contact your licensing/certification board to determine course eligibility for your licensing/certification requirement.

    Physicians / Nurses / Pharmacist

    In support of improving patient care, this activity has been planned and implemented by Amedco LLC and SITC.  Amedco LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation  Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


    Credit Designation Statement – Amedco LLC designates this enduring material for a maximum of 1.50 AMA PRA Category 1 CreditsTM for physicians, 1.50 contact hours for nurses, and 1.50 knowledge-based contact hours for pharmacists. Learners should claim only the credit commensurate with the extent of their participation in the activity.

    NOTE to Pharmacists: The only official Statement of Credit is the one you pull from CPE Monitor. You must request your certificate within 30 days of the activity to meet the deadline for submission to CPE Monitor.

    ABIM MOC Credit
    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.50 Part 2 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program.

    Disclosure of Conflict of Interest
    The following table of disclosure information is provided to learners and contains the relevant financial relationships that each individual in a position to control the content disclosed to Amedco.  All of these relationships were treated as a conflict of interest, and have been resolved.  (C7 SCS 6.1-­6.2, 6.5)

    All individuals in a position to control the content of CE are listed online. If their name is not listed below, they disclosed that they had no relevant financial relationships.
     

    FIRST NAME

    LAST NAME

    RELATIONSHIP:COMMERCIAL INTEREST

    Hussein

    Tawbi

    Genentech, BMS, Novartis, Merck, Array: Consulting Fees

    Genentech, BMS, Novartis, Merck, GSK: Contracted Research
     

    Silvia

    Formenti

    Grant/Research support from: Bristol Myers Squibb, Varian, Eli-Lilly, Janssen, Regeneron,Eisai, Merck: Contracted Research

    Bayer, Bristol Myers Squibb, Varian, ViewRay, Elekta, Janssen, Regeneron, GlaxoSmithKline, Eisai, Astra Zeneca, MedImmune, Merck US, EMD Serono/Merck, Accuray: Honoria


    Method of Participation and Request for Credit
    During the approved time period, 10/26/20 - 10/26/22, participants must read the learning objectives and faculty disclosures and study the educational activity.

    If you wish to receive acknowledgment for completing this activity, please follow the steps below:

    1. After completing the course, click My Credit from the left-hand side of the SITC connectED homepage.
    2. Under Pending Credit, click Request Credit for Certificate in Cancer Immunotherapy Module 2: Basic Cancer Immunotherapy Concepts.
    3. Ensure that the appropriate Credit Reporting Organization is selected. Click Continue.
    4. Successfully complete both the post-test with passing score of 80% or better and activity evaluation.
    5. Click Process Credit.
    6. Your Certificate will be available to view in the Submitted Credit section.

    For Pharmacists: Upon successfully completing the post-test with a score of 80% or better and the activity evaluation form, transcript information will be sent to the NABP CPE Monitor Service within 4 weeks.


    Media
    Internet

    Hardware and Software Requirements
    SITC connectED requires a modern web browser (Edge, Apple Safari, Google Chrome, Internet Explorer 7+) and the ability to listen to audio with the content.

    Disclosure of Unlabeled Use
    This educational activity may contain a discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

    The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

    Disclaimer
    Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

    Original Course Date: October 26, 2020
    On-Demand Release Date: Available Now

    Approved Credit:
  • ACCME (MD/DO): 1.50 hours AMA PRA Category 1 Credit(s)
  • ACCME (non-MD/DO): 1.50 hours AMA PRA Category 1 Credit(s)
  • CoP: 0.00 hours Certificate of Participation
  • : 1.50 hours AMA PRA Category 1 Credit(s)™ / ABIM Maintenance of Certification Part 2 Credit
  • ACPE: 1.50 hours Contact Hour
  • ANCC: 1.50 hours Contact Hour

  • MORE INFOMORE INFO Certificate in Cancer Immunotherapy Module 2: Basic Cancer Immunotherapy Concepts
    Collapse Certificate in Cancer Immunotherapy Module 3: Immune Checkpoint Blockade

    Published December 1, 2020

    Course Description
    This interactive online course is part of the Certificate in Cancer Immunotherapy program, produced by the Society for Immunotherapy of Cancer (SITC). The purpose of the certificate program is to provide hospitals, medical centers, third-party payers, referring physicians, trainees and patients with an identifiable designation for healthcare providers who can safely and effectively participate in administration of immunotherapies and manage patients treated with these approaches. View all eight modules of the program and a detailed description of the program here.

    This course, Module 3: Immune Checkpoint Blockade, will cover the biological foundation of immune checkpoint blockade therapies as well as diving into their clinical use.


    Click on image for FREE PREVIEW


     

     

     

     

     

     

     

     

     

     

    Target Audience
    The program is available to licensed physicians (U.S. licensed MD / DO or global equivalent). The courses and earning of the certificate (SITC-G; G = graduate) are also available to practicing, licensed NPs, PAs, and PharmDs or global equivalent. RPh degree holders are eligible if they are involved in direct clinical services. The courses are available to others who are not practicing clinicians, but they will not be eligible to earn the certificate.

    Faculty
    Robert L. Ferris, MD, PhD
    Hillman Professor of Oncology
    Director, UPMC Hillman Cancer Center
    Associate Vice Chancellor for Cancer Research
    University of Pittsburgh Medical Center, Pittsburgh, PA

     

    Learning Objectives

    Topic At the conclusion of this activity, the participant should be able to:

    Basic Mechanisms of Checkpoint
    Blockade in Immunotherapy

    • Describe the basis for co-stimulation in T cell activation and priming.
    • Explain the mechanisms and consequences of co-inhibitory immune checkpoint receptors (ICR).
    • Identify negative downstream regulatory motifs and pathways associated with ICR signaling.
    • Distinguish the distinct activities of antibodies that target PD-1 compared to those that target PD-L1

    Biomarkers of Response to ICB and General Clinical Utility

    • Describe major biomarkers for patient eligibility for the use of immune checkpoint blockade across cancers (PD-L1 expression and extent, IFN signature, CD8 infiltration, Tumor Mutational Burden) and their relative value for prediction of clinical benefit.
    • Distinguish between validated and investigational biomarkers.
    • Describe the use of biomarkers to predict ORR, PFS and OS.
    • Identify patient-specific factors that may predict response (tumor burden, prior chemotherapy exposure, age, gender, site of disease, prior radiotherapy, etc.).
    Immune Checkpoint Inhibitors and Combination Approaches
    • Describe general clinical benefits of ICB with PD-1 or CTLA-4 monotherapy, or ICB combinations (including IO+IO and IO+other cancer therapy combinations).
    • Distinguish the benefits, dose and schedules of combination ICB versus the benefits, dose and schedule of conventional therapies (chemotherapy, radiation therapy and targeted therapies).
    • Identify validated vs investigational ICB combinations, and relevant cancer types.
    Monitoring Response to Checkpoint Blockade
    • Distinguish response criteria in ICB vs standard cancer treatment.
    • Describe kinetics and patterns of response to ICB.
    • Distinguish pseudoprogression from true disease progression.
    • Identify when to suspend or discontinue ICB treatment.


     


    SITC Online Education Disclaimer

     

    A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or employing any therapies described in this educational activity.

     



    Continuing Education Information

    Date of CE Release:  December 1, 2020
    Date of CE Expiration: December 1, 2022
    Approximate Time to Complete:  90 minutes

    Acknowledgement of Financial Commercial Support
    No financial commercial support was received for this educational activity.

    Acknowledgement of In-Kind Commercial Support
    No in-kind commercial support was received for this educational activity.

    Satisfactory Completion

    Learners must listen to each self-directed audio recording while following along with the visual slides/read the articles, pass the post-test with a score of 80% or higher (unlimited attempts) and complete an evaluation form to receive a certificate of completion. You must participate in the entire activity as partial credit is not available. If you are seeking continuing education credit for a specialty not listed below, it is your responsibility to contact your licensing/certification board to determine course eligibility for your licensing/certification requirement.

    Physicians / Nurses / Pharmacist

    In support of improving patient care, this activity has been planned and implemented by Amedco LLC and SITC.  Amedco LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation  Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


    Credit Designation Statement – Amedco LLC designates this enduring material for a maximum of 1.50 AMA PRA Category 1 CreditsTM for physicians, 1.50 contact hours for nurses, and 1.50 knowledge-based contact hours for pharmacists. Learners should claim only the credit commensurate with the extent of their participation in the activity.

    NOTE to Pharmacists: The only official Statement of Credit is the one you pull from CPE Monitor. You must request your certificate within 30 days of the activity to meet the deadline for submission to CPE Monitor.

    ABIM MOC Credit
    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.50 Part 2 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program.

    Disclosure of Conflict of Interest
    The following table of disclosure information is provided to learners and contains the relevant financial relationships that each individual in a position to control the content disclosed to Amedco.  All of these relationships were treated as a conflict of interest, and have been resolved.  (C7 SCS 6.1-­6.2, 6.5)

    All individuals in a position to control the content of CE are listed online. If their name is not listed below, they disclosed that they had no relevant financial relationships.
     

    FIRST NAME

    LAST NAME

    RELATIONSHIP:COMMERCIAL INTEREST

    Robert

    Ferris

    Aduro Biotech, Inc; Amgen; Astra-Zeneca/MedImmune; Bain Capital Life Sciences; BMS; EMD Serono; GSK; Iovance Biotherapeutics, Inc; Lilly; MacroGenics, Inc; Merck; Nanobiotix; Numab Therapeutics AG; Oncorus, Inc; Ono Pharmaceutical Co. Ltd; Pfizer; PPD (Benitec, Immunicum); Regeneron Pharmaceuticals, Inc; Tesaro; Torque Therapeutics; TTMS; VentiRx Pharmaceuticals:Consulting Fees

    Astra-Zeneca/MedImmune; BMS; Merck; Tesaro; TTMS:Contracted Research

     

    Janssen, Eli Lilly, Scibase, DermTech, BMS, Pfizer:Partner Consulting Fees

     

    Regeneron, Janssen, BMS, Abbvie, Novartis, BI, Castle Biosciences, Eli Lilly: Partner Contracted Research

     

    Jose

    Lutzky

    Castle, Kimera Labs, Array, Iovance: Consulting Fees
     

    BMS, Novartis, Iovance, Replimune, Regeneron: Contracted Research


    Method of Participation and Request for Credit
    During the approved time period (12/1/20 - 12/1/22) participants must read the learning objectives and faculty disclosures and study the educational activity.

    If you wish to receive acknowledgment for completing this activity, please follow the steps below:

    1. After completing the course, click My Credit from the left-hand side of the SITC connectED homepage.
    2. Under Pending Credit, click Request Credit for Certificate in Cancer Immunotherapy Module 3: Immune Checkpoint Blockade.
    3. Ensure that the appropriate Credit Reporting Organization is selected. Click Continue.
    4. Successfully complete both the post-test with passing score of 80% or better and activity evaluation.
    5. Click Process Credit.
    6. Your Certificate will be available to view in the Submitted Credit section.

    For Pharmacists: Upon successfully completing the post-test with a score of 80% or better and the activity evaluation form, transcript information will be sent to the NABP CPE Monitor Service within 4 weeks.


    Media
    Internet

    Hardware and Software Requirements
    SITC connectED requires a modern web browser (Edge, Apple Safari, Google Chrome, Internet Explorer 7+) and the ability to listen to audio with the content.

    Disclosure of Unlabeled Use
    This educational activity may contain a discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

    The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

    Disclaimer
    Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

    Original Course Date: December 01, 2020
    On-Demand Release Date: Available Now

    Approved Credit:
  • ACCME (MD/DO): 1.50 hours AMA PRA Category 1 Credit(s)
  • ACCME (non-MD/DO): 1.50 hours AMA PRA Category 1 Credit(s)
  • CoP: 0.00 hours Certificate of Participation
  • : 1.50 hours AMA PRA Category 1 Credit(s)™ / ABIM Maintenance of Certification Part 2 Credit
  • ACPE: 1.50 hours Contact Hour
  • ANCC: 1.50 hours Contact Hour

  • MORE INFOMORE INFO Certificate in Cancer Immunotherapy Module 3: Immune Checkpoint Blockade
    Collapse Certificate in Cancer Immunotherapy Module 4: Managing Immune Checkpoint Inhibitor Adverse Events

    Coming soon!

    Course Description
    This interactive online course is part of the Certificate in Cancer Immunotherapy program, produced by the Society for Immunotherapy of Cancer (SITC). The purpose of the certificate program is to provide hospitals, medical centers, third-party payers, referring physicians, trainees and patients with an identifiable designation for healthcare providers who can safely and effectively participate in administration of immunotherapies and manage patients treated with these approaches. View all eight modules of the program and a detailed description of the program here.

    This course, Module 4: Managing Immune Checkpoint Inhibitor Adverse Events, will cover the presentations, diagnosis and management of adverse events resulting from immune checkpoint inhibitor treatments.


    Target Audience
    The program is available to licensed physicians (U.S. licensed MD / DO or global equivalent). The courses and earning of the certificate (SITC-G; G = graduate) are also available to practicing, licensed NPs, PAs, and PharmDs or global equivalent. RPh degree holders are eligible if they are involved in direct clinical services. The courses are available to others who are not practicing clinicians, but they will not be eligible to earn the certificate.

    Faculty
    Jason Luke, MD, FACP
    Associate Professor of Medicine, Division of Hematology/Oncology
    Director, Cancer Immunotherapeutics Center within the UPMC Hillman Cancer Immunology and Immunotherapy Program
    University of Pittsburch Medical Center, Pittsburgh, PA
     

    Learning Objectives

    Topic At the conclusion of this activity, the participant should be able to:

    Recognition, Frequency and Kinetics of Immune-Related Toxicities

    • Identify the immune-related toxicities associated with checkpoint inhibition.
    • Classify severity of immune related side effects.
    • Describe the kinetics of immune-related toxicities of immune checkpoint inhibition.
    • Distinguish immune-related side effects from those related to disease progression.
    • Recognize and manage hyperprogression.
    • Manage concurrent multiple adverse events.
    • Manage immunosuppressive medications used to treat adverse events.

    Management of Immune-Related
    Colitis

    • Describe how to diagnose immune-related colitis.
    • Describe the frequency and time to development of immune-related colitis associated with distinct immunotherapeutic drugs.
    • Manage grade 1/2 colitis and steroid refractory immune-related colitis.

    Management of Immune-Related Pneumonitis

    • Diagnose immune-related pneumonitis.
    • Describe the frequency of immune-related pneumonitis with distinct cancer types.
    • Manage immune-related pneumonitis.

    Management of Immune-Related Endocrinopathies

    • List immune-related endocrinopathies.
    • Recognize and diagnose immune-related endocrinopathies.
    • Treat immune-related endocrinopathies based on the severity of the toxicity.
    • Counsel patients about long term consequences and management of endocrinopathies.
    Management of Immune-Related
    Hepatitis
    • Recognize and diagnose immune-related hepatitis.
    • Treat immune-related hepatitis based on the severity of the toxicity.

    Management of Immune-Related
    Cutaneous Events

    • List immune-related cutaneous events.
    • Recognize and diagnose immune-related cutaneous events.
    • Treat immune-related cutaneous events based on the severity of the toxicity.

    Management of Other (Rare)
    Immune-related Adverse Events

    • List rare immune-related adverse events.
    • Recognize and diagnose rare immune-related adverse events.
    • Treat rare immune-related adverse events based on the severity of the toxicity.

    Unique aspects of IO-containing combination therapies

    • Describe the patterns and severity of adverse events with IO-containing combination therapies relative to the single agents.
    • Distinguish between immune-related and other toxicities in patients receiving IO-containing combination therapies.

    Chronic Toxicities Associated with
    Cancer Immunotherapy

    • List chronic toxicities of immunotherapy.
    • Describe the time course of chronic toxicities of immunotherapy.
    • Manage the chronic toxicities of immunotherapy.
    Management of Non-Immune-Mediated Adverse Events
    • List non-immune-mediated adverse events.
    • Recognize non-immune-mediated adverse events.
    • Treat non-immune-mediated adverse events.
    Management of ICB therapy in
    the Context of an Adverse Event
    • Describe when ICB therapy can be continued, reduced or discontinued in the face of toxicity.
    • Describe when ICB therapy can be reinstated following management of toxicity.


     


    SITC Online Education Disclaimer

     

    A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or employing any therapies described in this educational activity.

     



    Continuing Education Information

    Date of CE Release:  To be announced
    Date of CE Expiration: To be announced
    Approximate Time to Complete:  90 minutes

    Acknowledgement of Financial Commercial Support
    No financial commercial support was received for this educational activity.

    Acknowledgement of In-Kind Commercial Support
    No in-kind commercial support was received for this educational activity.

    Satisfactory Completion

    Learners must listen to each self-directed audio recording while following along with the visual slides/read the articles, pass the post-test with a score of 80% or higher (unlimited attempts) and complete an evaluation form to receive a certificate of completion. You must participate in the entire activity as partial credit is not available. If you are seeking continuing education credit for a specialty not listed below, it is your responsibility to contact your licensing/certification board to determine course eligibility for your licensing/certification requirement.

    Physicians / Nurses / Pharmacist

    In support of improving patient care, this activity has been planned and implemented by Amedco LLC and SITC.  Amedco LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation  Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


    Credit Designation Statement – Amedco LLC designates this enduring material for a maximum of 1.50 AMA PRA Category 1 CreditsTM for physicians, 1.50 contact hours for nurses, and 1.50 knowledge-based contact hours for pharmacists. Learners should claim only the credit commensurate with the extent of their participation in the activity.

    NOTE to Pharmacists: The only official Statement of Credit is the one you pull from CPE Monitor. You must request your certificate within 30 days of the activity to meet the deadline for submission to CPE Monitor.

    ABIM MOC Credit
    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.50 Part 2 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program.

    Disclosure of Conflict of Interest
    The following table of disclosure information is provided to learners and contains the relevant financial relationships that each individual in a position to control the content disclosed to Amedco.  All of these relationships were treated as a conflict of interest, and have been resolved.  (C7 SCS 6.1-­6.2, 6.5)

    All individuals in a position to control the content of CE are listed online. If their name is not listed below, they disclosed that they had no relevant financial relationships.
     

    FIRST NAME

    LAST NAME

    RELATIONSHIP:COMMERCIAL INTEREST

    To be updated before the launch of the module    


    Method of Participation and Request for Credit
    During the approved time period (to be announced) participants must read the learning objectives and faculty disclosures and study the educational activity.

    If you wish to receive acknowledgment for completing this activity, please follow the steps below:

    1. After completing the course, click My Credit from the left-hand side of the SITC connectED homepage.
    2. Under Pending Credit, click Request Credit for Certificate in Cancer Immunotherapy Module 4: Managing Immune Checkpoint Inhibitor Adverse Events.
    3. Ensure that the appropriate Credit Reporting Organization is selected. Click Continue.
    4. Successfully complete both the post-test with passing score of 80% or better and activity evaluation.
    5. Click Process Credit.
    6. Your Certificate will be available to view in the Submitted Credit section.

    For Pharmacists: Upon successfully completing the post-test with a score of 80% or better and the activity evaluation form, transcript information will be sent to the NABP CPE Monitor Service within 4 weeks.


    Media
    Internet

    Hardware and Software Requirements
    SITC connectED requires a modern web browser (Edge, Apple Safari, Google Chrome, Internet Explorer 7+) and the ability to listen to audio with the content.

    Disclosure of Unlabeled Use
    This educational activity may contain a discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

    The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

    Disclaimer
    Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

    Original Course Date: November 02, 2020
    On-Demand Release Date: Available Now

    Approved Credit:
  • ACCME (MD/DO): 1.50 hours AMA PRA Category 1 Credit(s)
  • ACCME (non-MD/DO): 1.50 hours AMA PRA Category 1 Credit(s)
  • CoP: 0.00 hours Certificate of Participation
  • : 1.50 hours AMA PRA Category 1 Credit(s)™ / ABIM Maintenance of Certification Part 2 Credit
  • ACPE: 1.50 hours Contact Hour
  • ANCC: 1.50 hours Contact Hour

  • MORE INFOMORE INFO Certificate in Cancer Immunotherapy Module 4: Managing Immune Checkpoint Inhibitor Adverse Events
    Collapse Certificate in Cancer Immunotherapy Module 5: Other Approaches (Cytokines, Vaccines, and Immune Cell Engagers)

    Coming soon!

    Course Description
    This interactive online course is part of the Certificate in Cancer Immunotherapy program, produced by the Society for Immunotherapy of Cancer (SITC). The purpose of the certificate program is to provide hospitals, medical centers, third-party payers, referring physicians, trainees and patients with an identifiable designation for healthcare providers who can safely and effectively participate in administration of immunotherapies and manage patients treated with these approaches. View all eight modules of the program and a detailed description of the program here.

    This course, Module 5: Other Approaches (Cytokines, Vaccines, and Immune Cell Engagers), will cover the biological foundation and clinical implementation of cytokines, vaccines and immune cell engagers as immunotherapies for cancer, including adverse event management.


    Target Audience
    The program is available to licensed physicians (U.S. licensed MD / DO or global equivalent). The courses and earning of the certificate (SITC-G; G = graduate) are also available to practicing, licensed NPs, PAs, and PharmDs or global equivalent. RPh degree holders are eligible if they are involved in direct clinical services. The courses are available to others who are not practicing clinicians, but they will not be eligible to earn the certificate.

    Faculty

    Bernard Fox, PhD
    Chief, Laboratory of Molecular and Tumor Immunology
    Harder Family Chair for Cancer Research
    Robert W. Franz Cancer Research Center
    Earle A. Chiles Research Institute
    Providence Cancer Center, Portland, OR
     

    Learning Objectives

    Topic At the conclusion of this activity, the participant should be able to:

    Basic Mechanisms

    • Define the types and functions of cytokines and chemokines used in cancer immunotherapy.
    • Distinguish among the various types of cancer vaccines.
    • Describe the different types and functions of tumor antigens used in cancer vaccines.
    • Classify the different delivery platforms for cancer vaccines.
    • Describe how personalized cancer vaccines differ from standard cancer vaccines.
    • Identify different methods and routes of administration of immunotherapy agents.
    • Define the types of immunologic adjuvants and their distinct functions in promoting immune responses.
    • Recognize the role of innate immune activators in promoting tumor immunotherapy.
    • Describe the mechanism of action of immune cell engagers.
    • Compare and contrast immune cell engagers with adoptive cellular therapies.
    • Describe potential mechanisms of relapse following immune cell engager therapies.

    Clinical Use and Development

    • Appreciate the historical data on vaccine and cytokine treatment of malignancy.
    • List current clinical indications for vaccines, cytokines, and immune cell engagers in cancer treatment.
    • Explain how immunologic boosting can enhance anti-tumor immunity with vaccines.
    • Describe the role of immunotherapy and vaccines in cancer prevention.
    • Characterize new and emerging vaccines, cytokines and immune cell engagers under clinical investigation.
    • Describe how cytokine levels may be used as prognostic and predictive biomarkers for cancer immunotherapy.

    Combination Approaches

    • Describe how cytokines, vaccines, and immune cell engagers can be combined with other immunotherapy agents to promote T cell recruitment and anti-tumor immunity.
    • Recognize the role of non-immune agents in promoting tumor immunity in combination with cytokines, vaccines, and immune cell engagers.
    • Define immunogenic cell death (ICD) and describe how combination approaches promote ICD and anti-tumor immunity.
    • Explain the abscopal effect of local therapy.
    • Describe how other agents can enhance immunotherapy.

    Patient Selection, Management and Monitoring

    • Apply criteria for patient selection for IL-2 or interferon therapy.
    • Identify contraindications to treatment with cytokines.
    • Describe methods needed to safely monitor patients on high-dose IL-2 therapy.
    • Describe criteria for patient selection for vaccine treatment.
    • Identify contraindications to treatment with vaccine therapy.
    • Describe patient selection criteria for immune cell engager therapies.
    • Identify contraindications to immune cell engager therapies.
    • Determine duration of treatment and when to assess patients for clinical response.

    Management of Adverse Events

    • Recognize the type and severity of adverse events associated with cytokine, vaccine, and immune cell engager administration.
    • Apply appropriate interventions to ameliorate toxicities associated with cytokines, vaccines, and immune cell engagers.  
    • Identify appropriate institutional and provider resources and procedures needed to manage cytokine-related toxicities.
    • Recognize the importance of continuing education for high-dose cytokine delivery teams.
    • Recognize the interactions between cytokines, vaccines, and immune cell engagers with other immunotherapy and non-immunotherapy cancer agents for causing unknown or unexpected adverse events.


     


    SITC Online Education Disclaimer

     

    A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or employing any therapies described in this educational activity.

     



    Continuing Education Information

    Date of CE Release:  To be announced
    Date of CE Expiration: To be announced
    Approximate Time to Complete:  90 minutes

    Acknowledgement of Financial Commercial Support
    No financial commercial support was received for this educational activity.

    Acknowledgement of In-Kind Commercial Support
    No in-kind commercial support was received for this educational activity.

    Satisfactory Completion

    Learners must listen to each self-directed audio recording while following along with the visual slides/read the articles, pass the post-test with a score of 80% or higher (unlimited attempts) and complete an evaluation form to receive a certificate of completion. You must participate in the entire activity as partial credit is not available. If you are seeking continuing education credit for a specialty not listed below, it is your responsibility to contact your licensing/certification board to determine course eligibility for your licensing/certification requirement.

    Physicians / Nurses / Pharmacist

    In support of improving patient care, this activity has been planned and implemented by Amedco LLC and SITC.  Amedco LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation  Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


    Credit Designation Statement – Amedco LLC designates this enduring material for a maximum of 1.50 AMA PRA Category 1 CreditsTM for physicians, 1.50 contact hours for nurses, and 1.50 knowledge-based contact hours for pharmacists. Learners should claim only the credit commensurate with the extent of their participation in the activity.

    NOTE to Pharmacists: The only official Statement of Credit is the one you pull from CPE Monitor. You must request your certificate within 30 days of the activity to meet the deadline for submission to CPE Monitor.

    ABIM MOC Credit
    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.50 Part 2 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program.

    Disclosure of Conflict of Interest
    The following table of disclosure information is provided to learners and contains the relevant financial relationships that each individual in a position to control the content disclosed to Amedco.  All of these relationships were treated as a conflict of interest, and have been resolved.  (C7 SCS 6.1-­6.2, 6.5)

    All individuals in a position to control the content of CE are listed online. If their name is not listed below, they disclosed that they had no relevant financial relationships.
     

    FIRST NAME

    LAST NAME

    RELATIONSHIP:COMMERCIAL INTEREST

    To be updated before the launch of the module    


    Method of Participation and Request for Credit
    During the approved time period (to be announced) participants must read the learning objectives and faculty disclosures and study the educational activity.

    If you wish to receive acknowledgment for completing this activity, please follow the steps below:

    1. After completing the course, click My Credit from the left-hand side of the SITC connectED homepage.
    2. Under Pending Credit, click Request Credit for Certificate in Cancer Immunotherapy Module 5: Other Approaches (Cytokines, Vaccines, and Immune Cell Engagers).
    3. Ensure that the appropriate Credit Reporting Organization is selected. Click Continue.
    4. Successfully complete both the post-test with passing score of 80% or better and activity evaluation.
    5. Click Process Credit.
    6. Your Certificate will be available to view in the Submitted Credit section.

    For Pharmacists: Upon successfully completing the post-test with a score of 80% or better and the activity evaluation form, transcript information will be sent to the NABP CPE Monitor Service within 4 weeks.


    Media
    Internet

    Hardware and Software Requirements
    SITC connectED requires a modern web browser (Edge, Apple Safari, Google Chrome, Internet Explorer 7+) and the ability to listen to audio with the content.

    Disclosure of Unlabeled Use
    This educational activity may contain a discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

    The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

    Disclaimer
    Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

    Original Course Date: December 07, 2020
    On-Demand Release Date: Available Now

    Approved Credit:
  • ACCME (MD/DO): 1.50 hours AMA PRA Category 1 Credit(s)
  • ACCME (non-MD/DO): 1.50 hours AMA PRA Category 1 Credit(s)
  • CoP: 0.00 hours Certificate of Participation
  • : 1.50 hours AMA PRA Category 1 Credit(s)™ / ABIM Maintenance of Certification Part 2 Credit
  • ACPE: 1.50 hours Contact Hour
  • ANCC: 1.50 hours Contact Hour

  • MORE INFOMORE INFO Certificate in Cancer Immunotherapy Module 5: Other Approaches (Cytokines, Vaccines, and Immune Cell Engagers)
    Collapse Certificate in Cancer Immunotherapy Module 6: Oncolytic Viruses and Intralesional Therapy

    Coming soon!

    Course Description
    This interactive online course is part of the Certificate in Cancer Immunotherapy program, produced by the Society for Immunotherapy of Cancer (SITC). The purpose of the certificate program is to provide hospitals, medical centers, third-party payers, referring physicians, trainees and patients with an identifiable designation for healthcare providers who can safely and effectively participate in administration of immunotherapies and manage patients treated with these approaches. View all eight modules of the program and a detailed description of the program here.

    This course, Module 6: Oncolytic Viruses and Intralesional Therapy, will cover the biological foundation and clinical implementation of intratumoral therapies and oncolytic viruses.


    Target Audience
    The program is available to licensed physicians (U.S. licensed MD / DO or global equivalent). The courses and earning of the certificate (SITC-G; G = graduate) are also available to practicing, licensed NPs, PAs, and PharmDs or global equivalent. RPh degree holders are eligible if they are involved in direct clinical services. The courses are available to others who are not practicing clinicians, but they will not be eligible to earn the certificate.

    Faculty

    Brian Gastman, MD
    Professor, Department of Surgery, School of Medicine
    Member, Hematopoietic and Immune Cancer Biology Program, Case Comprehensive Cancer Center
    Case Western Reserve University, Cleveland, OH
    Department of Plastic Surgery
    Cleveland Clinic Main Campus, Cleveland, OH

    Ann Silk, MD, MS
    Co-Director of the Merkel Cell Carcinoma Center of Excellence
    Dana-Farber Cancer Institute, Boston, MA
     

    Learning Objectives

    Topic At the conclusion of this activity, the participant should be able to:

    Basic Mechanisms of Oncolytic Viruses
    and Intralesional Therapy

    • Describe the rationale for intralesional therapy as a strategy for modulating tumor cells and promoting immunity.
    • Distinguish the differences between oncolytic viruses and non-viral intralesional approaches.  
    • Classify the different viruses available for cancer immunotherapy and their advantages and disadvantages.
    • List approved oncolytic viruses and intralesional agents.
    • Describe the dual mechanism of action of oncolytic viruses in mediating anti-tumor immunity.
    • Identify how oncolytic viruses can deliver transgenes to promote anti-tumor activity.
    • Describe alternative delivery routes of administration for oncolytic viruses and other intralesional agents.

    Patient Selection and Monitoring
    for Oncolytic Virus Therapies and Intralesional Therapy

    • Identify eligible patients for oncolytic viruses and intralesional therapy.
    • Determine when oncolytic viruses and/or intralesional therapy should be considered in patient management.
    • Select appropriate tumors for injection of an oncolytic virus and/or intralesional therapy.
    • Determine the volume of oncolytic virus and/or intralesional agent for patient therapy.
    • Describe the process of injecting oncolytic viruses and/or intralesional treatments in patients with cancer.
    • Identify the role of interventional radiology in administration of intralesional treatments to deep and/or visceral tumors.
    • Apply appropriate injection site management following injection of intralesional agents.
    • Define the patterns of response with oncolytic viruses and other intralesional treatments.
    • Identify contraindications to oncolytic virus and/or intralesional therapy.
    • Outline the potential role for oncolytic viruses and intralesional therapy as part of combination regimens for patients with cancer.

    Management of Oncolytic Virus and intralesional therapy Adverse Events

    • Identify the most common adverse events seen with oncolytic viruses and/or other intralesional treatments.
    • Prescribe appropriate intervention for managing common adverse events associated with oncolytic viruses and intralesional therapies.

    Logistical and Biosafety Issues
    Associated with Oncolytic Virus Therapy

    • Describe the biosafety issues associated with oncolytic virus administration.
    • Recognize the potential for bioshedding and contact transmission associated with oncolytic viruses.
    • Explain how to modify patient flow to optimize integration of oncolytic viruses and intralesional treatments into clinical practice.
    • Implement standard operating procedures for safe delivery of oncolytic viruses and intralesional treatments into clinical practice.


     


    SITC Online Education Disclaimer

     

    A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or employing any therapies described in this educational activity.

     



    Continuing Education Information

    Date of CE Release:  To be announced
    Date of CE Expiration: To be announced
    Approximate Time to Complete:  90 minutes

    Acknowledgement of Financial Commercial Support
    No financial commercial support was received for this educational activity.

    Acknowledgement of In-Kind Commercial Support
    No in-kind commercial support was received for this educational activity.

    Satisfactory Completion

    Learners must listen to each self-directed audio recording while following along with the visual slides/read the articles, pass the post-test with a score of 80% or higher (unlimited attempts) and complete an evaluation form to receive a certificate of completion. You must participate in the entire activity as partial credit is not available. If you are seeking continuing education credit for a specialty not listed below, it is your responsibility to contact your licensing/certification board to determine course eligibility for your licensing/certification requirement.

    Physicians / Nurses / Pharmacist

    In support of improving patient care, this activity has been planned and implemented by Amedco LLC and SITC.  Amedco LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation  Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


    Credit Designation Statement – Amedco LLC designates this enduring material for a maximum of 1.50 AMA PRA Category 1 CreditsTM for physicians, 1.50 contact hours for nurses, and 1.50 knowledge-based contact hours for pharmacists. Learners should claim only the credit commensurate with the extent of their participation in the activity.

    NOTE to Pharmacists: The only official Statement of Credit is the one you pull from CPE Monitor. You must request your certificate within 30 days of the activity to meet the deadline for submission to CPE Monitor.

    ABIM MOC Credit
    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.50 Part 2 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program.

    Disclosure of Conflict of Interest
    The following table of disclosure information is provided to learners and contains the relevant financial relationships that each individual in a position to control the content disclosed to Amedco.  All of these relationships were treated as a conflict of interest, and have been resolved.  (C7 SCS 6.1-­6.2, 6.5)

    All individuals in a position to control the content of CE are listed online. If their name is not listed below, they disclosed that they had no relevant financial relationships.
     

    FIRST NAME

    LAST NAME

    RELATIONSHIP:COMMERCIAL INTEREST

    To be updated before the launch of the module    


    Method of Participation and Request for Credit
    During the approved time period (to be announced) participants must read the learning objectives and faculty disclosures and study the educational activity.

    If you wish to receive acknowledgment for completing this activity, please follow the steps below:

    1. After completing the course, click My Credit from the left-hand side of the SITC connectED homepage.
    2. Under Pending Credit, click Request Credit for Certificate in Cancer Immunotherapy Module 6: Oncolytic Viruses and Intralesional Therapy.
    3. Ensure that the appropriate Credit Reporting Organization is selected. Click Continue.
    4. Successfully complete both the post-test with passing score of 80% or better and activity evaluation.
    5. Click Process Credit.
    6. Your Certificate will be available to view in the Submitted Credit section.

    For Pharmacists: Upon successfully completing the post-test with a score of 80% or better and the activity evaluation form, transcript information will be sent to the NABP CPE Monitor Service within 4 weeks.


    Media
    Internet

    Hardware and Software Requirements
    SITC connectED requires a modern web browser (Edge, Apple Safari, Google Chrome, Internet Explorer 7+) and the ability to listen to audio with the content.

    Disclosure of Unlabeled Use
    This educational activity may contain a discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

    The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

    Disclaimer
    Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

    Original Course Date: January 04, 2021
    On-Demand Release Date: Available Now

    Approved Credit:
  • ACCME (MD/DO): 1.50 hours AMA PRA Category 1 Credit(s)
  • ACCME (non-MD/DO): 1.50 hours AMA PRA Category 1 Credit(s)
  • CoP: 0.00 hours Certificate of Participation
  • : 1.50 hours AMA PRA Category 1 Credit(s)™ / ABIM Maintenance of Certification Part 2 Credit
  • ACPE: 1.50 hours Contact Hour
  • ANCC: 1.50 hours Contact Hour

  • MORE INFOMORE INFO Certificate in Cancer Immunotherapy Module 6: Oncolytic Viruses and Intralesional Therapy
    Collapse Certificate in Cancer Immunotherapy Module 7: CAR T Cell and Cellular Therapy

    Coming soon!

    Course Description
    This interactive online course is part of the Certificate in Cancer Immunotherapy program, produced by the Society for Immunotherapy of Cancer (SITC). The purpose of the certificate program is to provide hospitals, medical centers, third-party payers, referring physicians, trainees and patients with an identifiable designation for healthcare providers who can safely and effectively participate in administration of immunotherapies and manage patients treated with these approaches. View all eight modules of the program and a detailed description of the program here.

    This course, Module 7: CAR T Cell and Cellular Therapy, will cover the mechanisms and clinical administration of cellular therapies for cancer, including an emphasis on adverse event management.


    Target Audience
    The program is available to licensed physicians (U.S. licensed MD / DO or global equivalent). The courses and earning of the certificate (SITC-G; G = graduate) are also available to practicing, licensed NPs, PAs, and PharmDs or global equivalent. RPh degree holders are eligible if they are involved in direct clinical services. The courses are available to others who are not practicing clinicians, but they will not be eligible to earn the certificate.

    Faculty
    Carl June, MD
    Richard W. Vague Professor In Immunotherapy, Department of Pathology and Laboratory Medicine
    Director, Parker Institute for Cancer Immunotherapy
    Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
     

    Learning Objectives

    Topic At the conclusion of this activity, the participant should be able to:

    Basic Mechanisms of Adoptive T Cell Immunotherapy

    • Describe the biologic basis for adoptive T cell therapy of cancer.
    • Define significance of different target antigens and signaling moieties in CAR T cell activity.
    • Contrast the differences between CAR T and other adoptive T cell strategies.
    • Distinguish between different CAR T preparations such as target antigen but also viral vector culture conditions and signaling moieties.

    Cellular therapies and Current Clinical Indications

    • Classify the types of adoptive T cell therapies approved for cancer treatment.
    • Describe clinical indications of approved therapies.
    • Describe off-label uses of CAR T cell therapy.

    Patient Selection for
    T Cell-based Therapy

    • Identify when patients should be referred for cellular therapy.
    • Recognize contraindications to adoptive cell administration.
    • Describe the timeline of adoptive cellular therapy preparation and administration.

    Management of CAR T Cell
    Administration and Adverse Events

    • Describe the preparation of CAR T and patient disease management prior to administration.
    • Recognize the different types and patterns of CAR T-related toxicity.
    • Outline approaches to monitoring patients for CAR T-related toxicity including cytokine release syndrome and neurotoxicity.
    • Describe grading and management of cytokine release syndrome and neurotoxicity.
    • Describe typical kinetics of response of malignancy to CAR T cell therapy.
    • Describe long term monitoring and management of CAR T cell patients including identification and management of long term toxicities such as cytopenias and immuno-deficiency.
    • Describe the resources required for outpatient management of CAR T cell therapy

    Requirements for CAR T Cell Program Development

    • Describe the requirements for site certification for administering cellular therapies, including REMS training.
    • Identify other medical specialists who need to participate in REMS training and care of CAR T patients.
    • Outline data reporting requirements for CAR T cell programs.
    • Describe in-patient versus out-patient management and monitoring of CAR T cell patients.


     


    SITC Online Education Disclaimer

     

    A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or employing any therapies described in this educational activity.

     



    Continuing Education Information

    Date of CE Release:  To be announced
    Date of CE Expiration: To be announced
    Approximate Time to Complete:  90 minutes

    Acknowledgement of Financial Commercial Support
    No financial commercial support was received for this educational activity.

    Acknowledgement of In-Kind Commercial Support
    No in-kind commercial support was received for this educational activity.

    Satisfactory Completion

    Learners must listen to each self-directed audio recording while following along with the visual slides/read the articles, pass the post-test with a score of 80% or higher (unlimited attempts) and complete an evaluation form to receive a certificate of completion. You must participate in the entire activity as partial credit is not available. If you are seeking continuing education credit for a specialty not listed below, it is your responsibility to contact your licensing/certification board to determine course eligibility for your licensing/certification requirement.

    Physicians / Nurses / Pharmacist

    In support of improving patient care, this activity has been planned and implemented by Amedco LLC and SITC.  Amedco LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation  Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


    Credit Designation Statement – Amedco LLC designates this enduring material for a maximum of 1.50 AMA PRA Category 1 CreditsTM for physicians, 1.50 contact hours for nurses, and 1.50 knowledge-based contact hours for pharmacists. Learners should claim only the credit commensurate with the extent of their participation in the activity.

    NOTE to Pharmacists: The only official Statement of Credit is the one you pull from CPE Monitor. You must request your certificate within 30 days of the activity to meet the deadline for submission to CPE Monitor.

    ABIM MOC Credit
    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.50 Part 2 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program.

    Disclosure of Conflict of Interest
    The following table of disclosure information is provided to learners and contains the relevant financial relationships that each individual in a position to control the content disclosed to Amedco.  All of these relationships were treated as a conflict of interest, and have been resolved.  (C7 SCS 6.1-­6.2, 6.5)

    All individuals in a position to control the content of CE are listed online. If their name is not listed below, they disclosed that they had no relevant financial relationships.
     

    FIRST NAME

    LAST NAME

    RELATIONSHIP:COMMERCIAL INTEREST

    To be updated before the launch of the module    


    Method of Participation and Request for Credit
    During the approved time period (to be announced) participants must read the learning objectives and faculty disclosures and study the educational activity.

    If you wish to receive acknowledgment for completing this activity, please follow the steps below:

    1. After completing the course, click My Credit from the left-hand side of the SITC connectED homepage.
    2. Under Pending Credit, click Request Credit for Certificate in Cancer Immunotherapy Module 7: CAR T Cell and Cellular Therapy.
    3. Ensure that the appropriate Credit Reporting Organization is selected. Click Continue.
    4. Successfully complete both the post-test with passing score of 80% or better and activity evaluation.
    5. Click Process Credit.
    6. Your Certificate will be available to view in the Submitted Credit section.

    For Pharmacists: Upon successfully completing the post-test with a score of 80% or better and the activity evaluation form, transcript information will be sent to the NABP CPE Monitor Service within 4 weeks.


    Media
    Internet

    Hardware and Software Requirements
    SITC connectED requires a modern web browser (Edge, Apple Safari, Google Chrome, Internet Explorer 7+) and the ability to listen to audio with the content.

    Disclosure of Unlabeled Use
    This educational activity may contain a discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

    The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

    Disclaimer
    Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

    Original Course Date: February 01, 2021
    On-Demand Release Date: Available Now

    Approved Credit:
  • ACCME (MD/DO): 1.50 hours AMA PRA Category 1 Credit(s)
  • ACCME (non-MD/DO): 1.50 hours AMA PRA Category 1 Credit(s)
  • CoP: 0.00 hours Certificate of Participation
  • : 1.50 hours AMA PRA Category 1 Credit(s)™ / ABIM Maintenance of Certification Part 2 Credit
  • ACPE: 1.50 hours Contact Hour
  • ANCC: 1.50 hours Contact Hour

  • MORE INFOMORE INFO Certificate in Cancer Immunotherapy Module 7: CAR T Cell and Cellular Therapy
    Collapse Certificate in Cancer Immunotherapy Module 8: Implementing Cancer Immunotherapy in Clinical Practice

    Coming soon!

    Course Description
    This interactive online course is part of the Certificate in Cancer Immunotherapy program, produced by the Society for Immunotherapy of Cancer (SITC). The purpose of the certificate program is to provide hospitals, medical centers, third-party payers, referring physicians, trainees and patients with an identifiable designation for healthcare providers who can safely and effectively participate in administration of immunotherapies and manage patients treated with these approaches. View all eight modules of the program and a detailed description of the program here.

    This course, Module 8: Implementing Cancer Immunotherapy in Clinical Practice, will cover the practical aspects of instituting immunotherapy treatments in a clinical practice, such as education considerations, value-based care, and access to patient and provider resources.


    Target Audience
    The program is available to licensed physicians (U.S. licensed MD / DO or global equivalent). The courses and earning of the certificate (SITC-G; G = graduate) are also available to practicing, licensed NPs, PAs, and PharmDs or global equivalent. RPh degree holders are eligible if they are involved in direct clinical services. The courses are available to others who are not practicing clinicians, but they will not be eligible to earn the certificate.

    Faculty
    Sigrun Hallmeyer, MD
    Director, Advocate Medical Group
    Member, Division of Hematology/Oncology
    Advocate Lutheran General Hospital, Park Ridge, IL
     

    Learning Objectives

    Topic At the conclusion of this activity, the participant should be able to:

    How Cancer Immunotherapy Integrates
    into Value-based Clinical Care

    • Contrast the role of IO versus standard cancer therapies in the setting of personalized care approaches.
    • Evaluate IO in the NCCN/ASCO value framework.
    • Interpret published data on Patient Reported Outcomes.
    • Analyze cost of IO in the setting of quality of life, earning potential preserved, duration of response, and duration of therapy.

    Optimizing Resources for Cancer Immunotherapy Patient Care

    • Identify and access local, regional and national support foundations and financial support programs.
    • Identify patient education resources.
    • Tailor patient and staff communication to the dynamic and complex nature of IO, including continuous education strategies, telemedicine, etc.

    Educating Non-cancer Professionals
    about Cancer Immunotherapy

    • Build a dedicated multidisciplinary team with expertise in immuno-oncology administration, adverse events diagnosis and management.
    • Develop subspecialty-targeted learning programs for education on IO.
    • Identify best practices of communicating with primary care physicians and emergency physician on how to recognize treatment related adverse events.

    Patient Selection in Immunotherapy

    • Interpret the value and limitations of current biomarkers in different IO settings.
    • Distinguish the risk/benefit ratios for each individual case based on published data, expert opinion or personal experience.
    • Describe the key elements of a detailed informed consent discussion.
    • Describe IO therapy in populations traditionally deemed ineligible for clinical trials 


     


    SITC Online Education Disclaimer

     

    A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or employing any therapies described in this educational activity.

     



    Continuing Education Information

    Date of CE Release:  To be announced
    Date of CE Expiration: To be announced
    Approximate Time to Complete:  90 minutes

    Acknowledgement of Financial Commercial Support
    No financial commercial support was received for this educational activity.

    Acknowledgement of In-Kind Commercial Support
    No in-kind commercial support was received for this educational activity.

    Satisfactory Completion

    Learners must listen to each self-directed audio recording while following along with the visual slides/read the articles, pass the post-test with a score of 80% or higher (unlimited attempts) and complete an evaluation form to receive a certificate of completion. You must participate in the entire activity as partial credit is not available. If you are seeking continuing education credit for a specialty not listed below, it is your responsibility to contact your licensing/certification board to determine course eligibility for your licensing/certification requirement.

    Physicians / Nurses / Pharmacist

    In support of improving patient care, this activity has been planned and implemented by Amedco LLC and SITC.  Amedco LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation  Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


    Credit Designation Statement – Amedco LLC designates this enduring material for a maximum of 1.50 AMA PRA Category 1 CreditsTM for physicians, 1.50 contact hours for nurses, and 1.50 knowledge-based contact hours for pharmacists. Learners should claim only the credit commensurate with the extent of their participation in the activity.

    NOTE to Pharmacists: The only official Statement of Credit is the one you pull from CPE Monitor. You must request your certificate within 30 days of the activity to meet the deadline for submission to CPE Monitor.

    ABIM MOC Credit
    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.50 Part 2 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program.

    Disclosure of Conflict of Interest
    The following table of disclosure information is provided to learners and contains the relevant financial relationships that each individual in a position to control the content disclosed to Amedco.  All of these relationships were treated as a conflict of interest, and have been resolved.  (C7 SCS 6.1-­6.2, 6.5)

    All individuals in a position to control the content of CE are listed online. If their name is not listed below, they disclosed that they had no relevant financial relationships.
     

    FIRST NAME

    LAST NAME

    RELATIONSHIP:COMMERCIAL INTEREST

    To be updated before the launch of the module    


    Method of Participation and Request for Credit
    During the approved time period (to be announced) participants must read the learning objectives and faculty disclosures and study the educational activity.

    If you wish to receive acknowledgment for completing this activity, please follow the steps below:

    1. After completing the course, click My Credit from the left-hand side of the SITC connectED homepage.
    2. Under Pending Credit, click Request Credit for Certificate in Cancer Immunotherapy Module 8: Implementing Cancer Immunotherapy in Clinical Practice.
    3. Ensure that the appropriate Credit Reporting Organization is selected. Click Continue.
    4. Successfully complete both the post-test with passing score of 80% or better and activity evaluation.
    5. Click Process Credit.
    6. Your Certificate will be available to view in the Submitted Credit section.

    For Pharmacists: Upon successfully completing the post-test with a score of 80% or better and the activity evaluation form, transcript information will be sent to the NABP CPE Monitor Service within 4 weeks.


    Media
    Internet

    Hardware and Software Requirements
    SITC connectED requires a modern web browser (Edge, Apple Safari, Google Chrome, Internet Explorer 7+) and the ability to listen to audio with the content.

    Disclosure of Unlabeled Use
    This educational activity may contain a discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

    The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

    Disclaimer
    Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

    Original Course Date: March 01, 2021
    On-Demand Release Date: Available Now

    Approved Credit:
  • ACCME (MD/DO): 1.50 hours AMA PRA Category 1 Credit(s)
  • ACCME (non-MD/DO): 1.50 hours AMA PRA Category 1 Credit(s)
  • CoP: 0.00 hours Certificate of Participation
  • : 1.50 hours AMA PRA Category 1 Credit(s)™ / ABIM Maintenance of Certification Part 2 Credit
  • ACPE: 1.50 hours Contact Hour
  • ANCC: 1.50 hours Contact Hour

  • MORE INFOMORE INFO Certificate in Cancer Immunotherapy Module 8: Implementing Cancer Immunotherapy in Clinical Practice

    Audience: The program is available to licensed physicians (U.S. licensed MD / DO or global equivalent). The courses and earning of the certificate (SITC-G; G = graduate) are also available to practicing, licensed NPs, PAs, and PharmDs or global equivalent. RPh degree holders are eligible if they are involved in direct clinical services. The courses are available to others who are not practicing clinicians, but they will not be eligible to earn the certificate. 

    Purpose: The purpose of the certificate program is to provide hospitals, medical centers, third-party payers, referring physicians, trainees and patients with an identifiable designation for healthcare providers who can safely and effectively participate in administration of immunotherapies and manage patients treated with these approaches.

    Requirements: The requirements to earn the certificate include: 

         - Must be a treating physician (U.S. licensed MD / DO or global equivalent), or a practicing licensed NP, PA, PharmD or RPh degree holder involved in direct clinical services, or global equivalent 
         - Complete the coursework (all eight modules) - approximately 1.5 hours each for a total of 12-16 hours 
         - Pass all end-of-module assessments 
         - Successfully complete a comprehensive exam covering all modules

    Cost Per Module:  
    SITC Member: $25.00 
    Non-Member: $31.25

    The certificate term will be 2 years. After that, to earn a current certificate which allows one to continue to use the SITC-G designation, an individual would need to take and pass updated coursework and assessments. If one misses the deadline for reissuance, he or she would need to retake and pass the full program.